Newsletter February 2003
This newsletter provides an update on the D:A:D study, started in 1999 to assess whether combination anti-retroviral drugs accelerate the risk of cardiovascular disease.
Recently the process of completing the third merger of the data was completed. A total of 23,468 patients have now been included in the study providing 36,200 years of prospective follow-up. More than 90% of the patients have recent follow-up information. We encourage the sites to continue to follow closely patients involved in D:A:D and to promptly report any case of cardiovascular disease to the coordinating centre. Also, please provide details on all causes of death using the new version of the form for fatal cases. D:A:D has received funding that will allow the study to continue until through the first quarter of 2005.
The final analysis and scientific findings based on the 3rd merger have recently been completed. The 3rd merger contains information on follow-up through January 2002. The essentials will be presented at the upcoming CROI meeting in Boston on Thursday, Feb. 13th during the morning session (presenting author: N Friis-Møller). A position statement will appear on the web site (www.cphiv.dk) immediately after the presentation. We kindly refer you to this document. Already posted on the web site are the essential characteristics of the cohort at baseline. Based on the data, a manuscript is currently submitted for peer-review.
The first manuscript from the D:A:D collaboration (Law et al) was published in the January issue of HIV Medicine (read article) . The article describes the results of modeling various expected outcome scenarios based on baseline information. This is interesting when comparing the results of the actual observed outcome to the models. A second paper, extensively describing the cohort at baseline, is in press at AIDS.
Please continue to check this web site for updates. 2003 will be an important year for D:A:D.
|Nina Friis-Møller, MD
||Study Datamanager |
|Jens D. Lundgren, MD
|Chair, Steering Committeee|
Updated: 13 Jan 2006