Studies * ProbeC
    Hepatitis coinfection

    HIV/HCV. The PROBE-C Study

    An emerging problem worldwide is the epidemics of acute hepatitis C in HIV-positive men who have sex with men (MSM), firstly described in London in the beginning of 2000, and subsequently reported by several investigators in different countries. NEAT initial plan was to conduct a multinational clinical trial to test efficacy and safety of different treatments for this condition. However, two main considerations led NEAT General Assembly to modify the plan: the high costs of this study and the several controversies existing in the field. Indeed, the natural history of the disease and its actual incidence are still unknown. Therefore, a “hepatitis group” has been set up within NEAT that includes the major experts in the field and contributors to > 90% of published cases on acute HCV infection. This group will work at establishing a cohort of patients for the PRospective OBservational Evaluation (PROBE) study on the natural history and treatment of acute HCV in HIV positive individuals in Europe. Besides collecting unique information on this new epidemics, PROBE will provide a clinical platform to explore safety and efficacy of different treatment approaches.

    List of partners involved in the study

    AP-HP, Hôpital La Pitié Salpétrière, Paris, France Brigitte Autran
    Stephanie Dominguez
    Marguerite Guiguet
    Christine Katlama
    Marc-Antoine Valantin
    Hospital Carlos III, Madrid, Spain Francisco Blanco
    Vincent Soriano
    Fundacio Lluita contra la SIDA, Barcelona, Spain Bonaventura Clotet
    Cristina Tural
    Saint Pierre University Hospital, Brussels, Belgium Nathan Clumeck
    Università degli studi di Milano, Italy Massimo Galli
    European AIDS Treatment Group, Brussels, Belgium Diego Garcia
    Hospital Clinic i Provincial de Barcelona, Spain Jose Gatell
    Jose Mallola
    University College London, United Kingdom Richard Gilson
    Wojewodzki Szpital Zakazny, Warsaw, Poland Andrzej Horban
    University of Bonn, Germany Guido Lüchters
    Jürgen K. Rockstroh
    Martin Vogel
    Christoph Boesecke
    Svetlana Hass
    Medical School Hannover, Germany Dirk Meyer-Olson
    Reinhold Schmidt
    St. Stephens AIDS Trust / Chelsea Westminster Hospital, London, United Kingdom Mark Nelson
    Emma Page
    Centre of excellence for Health, immunity and Infections, CHIP, Denmark Lars Peters
    Università degli Studi di Brescia Institute of Infectious and tropical diseases, Italy Massimo Puoti
    Academisch Medisch Centrum, Amsterdam, The Netherlands Peter Reiss
    University of Frankfurt / Main, Germany Christoph Stephan
    Markus Bickel
    Pavel Khaykin