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Substudies

Due to the size of the START trial, its anticipated diversity of recruitment, rigorous methodology and conduct, and the primary hypothesis under investigation, it is an ideal vehicle for the execution of hypothesis-driven substudies. A number of funding agencies have supported the trial on the basis of including nested substudies:

Informed Consent substudy

Monitoring substudy

Genomics substudy

Neurology substudy

Arterial Elasticity substudy

Pulmonary substudy

Bone Mineral Density substudy

Liver Fibrosis substudy